Low density polyethylene functionalized with antibiofilm compounds inhibits Escherichia coli cell adhesion.
Silvia Dell'ortoCristina CattòFederica VillaFabio ForlaniEspedito VassalloMarco MorraFrancesca CappitelliStefania VillaArianna GelainPublished in: Journal of biomedical materials research. Part A (2017)
The present work concerns an efficient strategy to obtain novel medical devices materials able to inhibit biofilm formation. The new materials were achieved by covalent grafting of p-aminocinnamic or p-aminosalicylic acids on low density polyethylene coupons. The polyethylene surface, previously activated by oxygen plasma treatment, was functionalized using 2-hydroxymethylmetacrylate as linker. The latter was reacted with succinic anhydride affording the carboxylic end useful for the immobilization of the antibiofilm molecules. The modified surface was characterized by scanning electron microscope, X-ray photoelectron spectroscopy, attenuated total reflectance Fourier transform infrared and fluorescence analyses. The antibiofilm activity of the modified materials were tested against Escherichia coli biofilm grown in the Center of Disease Control biofilm reactor. The results revealed that the grafted cinnamic and salicylic acid derivatives reduced biofilm biomass, in comparison with the control, by 73.7 ± 10.7% and 63.4 ± 7.1%, respectively. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 3251-3261, 2017.
Keyphrases
- biofilm formation
- escherichia coli
- pseudomonas aeruginosa
- candida albicans
- staphylococcus aureus
- cell adhesion
- high resolution
- electron microscopy
- wastewater treatment
- single molecule
- quantum dots
- cystic fibrosis
- anaerobic digestion
- single cell
- magnetic resonance
- magnetic resonance imaging
- energy transfer
- combination therapy
- computed tomography
- multidrug resistant
- structure activity relationship
- breast reconstruction
- solid state