Genome-wide association study of dermatomyositis reveals genetic overlap with other autoimmune disorders.
Frederick W MillerRobert G CooperJiří VencovskýLisa G RiderKatalin DankoLucy R WedderburnIngrid E LundbergLauren M PachmanAnn M ReedSteven R YtterbergLeonid PadyukovAlbert Selva-O'CallaghanTimothy R D J RadstakeDavid A IsenbergHector ChinoyWilliam E R OllierTerrance P O'HanlonBo PengAnnette LeeJanine A LambWei ChenChristopher I AmosPeter K Gregersennull nullPublished in: Arthritis and rheumatism (2014)
Our findings confirm the MHC as the major genetic region associated with DM and indicate that DM shares non-MHC genetic features with other autoimmune diseases, suggesting the presence of additional novel risk loci. This first identification of autoimmune disease genetic predispositions shared with DM may lead to enhanced understanding of pathogenesis and novel diagnostic and therapeutic approaches.