Asymmetric Total Synthesis of Meptazinol.
Tobias BablAnd Oliver ReiserPublished in: The Journal of organic chemistry (2022)
The first enantioselective synthesis of ( S )-meptazinol in 14 steps from commercially available ethyl 4-oxo-3,4-dihydropyridine-1(2 H )-carboxylate, being widely used in racemic form for pain treatment, and, en route, the formal synthesis of two anti-Alzheimer's agents are reported. A novel ring expansion of 2-azabicyclo[4.1.0]heptanes, readily available via the stereoselective cyclopropanation of 1,2,3,4-tetrahydropyridine-4-ols, provides an effective entry to 3,3-disubstituted azepanes that represent the core for a variety of approved drugs.