Low peripheral blood derived neutrophil-to-lymphocyte ratio (dNLR) is associated with increased tumor T-cell infiltration and favorable outcomes to first-line pembrolizumab in non-small cell lung cancer.
Joao M Victor AlessiBiagio RicciutiStephanie L AldenArrien A BertramJessica J LinMustafa SakhiMizuki NishinoVictor R VazJames LindsayMadison M TurnerKathleen PfaffBijaya SharmaKristen D FeltScott J RodigJustin F GainorMark M AwadPublished in: Journal for immunotherapy of cancer (2021)
Among patients with NSCLC and a PD-L1 TPS ≥50%, a low dNLR has a distinct immune tumor microenvironment and more favorable outcomes to first-line pembrolizumab.