Gastric cancer mesenchymal stem cells via the CXCR2/HK2/PD-L1 pathway mediate immunosuppression.

Chao HuangBin ChenXin WangJuan XuLi SunDeqiang WangYuanyuan ZhaoChenglin ZhouQiuzhi GaoQianqian WangZhihong ChenMei WangXu ZhangWenrong XuBo ShenWei Zhu

Published in: Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association (2023)

Our findings reveal that blocking GCMSCs-derived IL-8/CXCR2 pathway decreasing PD-L1 expression and lactate production, improving antitumor efficacy of anti-PD-1 immunotherapy, may be of value for the treatment of advanced gastric carcinoma.

Keyphrases

mesenchymal stem cells
cell migration
umbilical cord
stem cells
gene expression
genome wide
dna methylation
smoking cessation