Identification and validation of obesity-related gene LEP methylation as a prognostic indicator in patients with acute myeloid leukemia.
Ting-Juan ZhangZi-Jun XuYu GuJi-Chun MaXiang-Mei WenWei ZhangZhao-Qun DengJun QianJiang LinJing-Dong ZhouPublished in: Clinical epigenetics (2021)
Our findings indicated that the obesity-related gene LEP methylation is associated with LEP inactivation, and acts as an independent prognostic predictor in AML.
Keyphrases
- acute myeloid leukemia
- genome wide
- insulin resistance
- metabolic syndrome
- weight loss
- type diabetes
- dna methylation
- copy number
- weight gain
- high fat diet induced
- allogeneic hematopoietic stem cell transplantation
- genome wide identification
- adipose tissue
- skeletal muscle
- transcription factor
- acute lymphoblastic leukemia
- physical activity
- genome wide analysis