Insights From a Large-Scale Whole-Genome Sequencing Study of Systolic Blood Pressure, Diastolic Blood Pressure, and Hypertension.
Tanika N KellyXiao SunKaren Y HeMichael R BrownSarah A Gagliano TaliunJacklyn N HellwegeMarguerite R IrvinXuenan MiJennifer A BrodyNora FranceschiniXiuqing GuoShih-Jen HwangPaul S de VriesYan GaoArden MoscatiGirish Nitin NadkarniLisa R YanekTali ElfassyJennifer A SmithRen-Hua ChungAmber L BeitelsheesAmit PatkiStella AslibekyanBrandon M BlobnerJuan M PeraltaThemistocles L AssimesWalter R PalmasChunyu LiuAdam P BressZhijie HuangLewis C BeckerChii-Min HwaJeffrey R O'ConnellJenna C CarlsonHelen R WarrenSayantan DasAyush GiriLisa Warsinger MartinW Craig JohnsonErvin R FoxErwin P BöttingerAlexander C RazaviR Dhananjay VaidyaLee-Ming ChuangYen-Pei C ChangTake NaseriDeepti JainHyun Min KangAdriana M HungVinodh SrinivasasainagendraBeverly M SnivelyDongfeng GuMay E MontasserMuagututi'a Sefuiva ReupenaBenjamin D HeavnerJonathon LeFaiveJames E HixsonKenneth M RiceFei Fei WangJonas Bille NielsenJianfeng HuangAlyna T KhanWei ZhouJovia L NierenbergCathy C LaurieNicole D ArmstrongMengyao ShiYang PanAdrienne M StilpLeslie S EmeryQuenna WongNicola L HawleyRyan L MinsterJoanne E CurranPatricia B MunroeDaniel E WeeksKari E NorthRussell P TracyEimear E KennyDaichi ShimboAravinda ChakravartiStephen S RichAlexander P ReinerJohn E BlangeroSusan RedlineBraxton D MitchellDabeeru C RaoYii-Der Ida ChenSharon L R KardiaRobert C KaplanRasika A MathiasJiang HeBruce M PsatyMyriam FornageRuth J F LoosAdolfo CorreaEric BoerwinkleJerome I RotterCharles KooperbergTodd L EdwardsGonçalo R AbecasisXiaofeng ZhuDaniel LevyDonna K ArnettAlanna C Morrisonnull nullPublished in: Hypertension (Dallas, Tex. : 1979) (2022)
We report one promising but unconfirmed rare variant for blood pressure and, more importantly, contribute insights for future blood pressure sequencing studies. Our findings suggest promise of aggregate analyses to complement single variant analysis strategies and the need for larger, diverse samples, and family studies to enable robust rare variant identification.