Epithelial ovarian cancer and brain metastases: might the BRCA status, PARP inhibitor administration, and surgical treatment impact the survival?
Carolina Maria SassuClaudia MarchettiGiorgia RussoAngelo MinucciSerena Maria BocciaAlberto BenatoCamilla NeroAlessia PiermatteiPier Paolo MattognoDiana GiannarelliGabriella FerrandinaAlessandro OliviAnna FagottiGiovanni ScambiaPublished in: International journal of gynecological cancer : official journal of the International Gynecological Cancer Society (2024)
mutations might impact brain metastasis occurrence and lead to better outcomes. In a multimodal treatment, surgery seems to affect survival even in cases of extracranial disease. PARPi use should be considered as it seems to prolong survival if administered after brain metastasis.
Keyphrases
- brain metastases
- small cell lung cancer
- free survival
- resting state
- white matter
- minimally invasive
- risk assessment
- dna damage
- functional connectivity
- cerebral ischemia
- multiple sclerosis
- type diabetes
- coronary artery bypass
- internal carotid artery
- adipose tissue
- insulin resistance
- acute coronary syndrome
- atrial fibrillation
- percutaneous coronary intervention
- subarachnoid hemorrhage
- breast cancer risk