The role of family history in predicting germline pathogenic variant carriers who develop pancreatic cancer: Results of a multicenter collaboration.
Eve KarloskiBeth DudleyBrenda DiergaardeAmie BlancoJessica N EverettElana LevinsonTara RangarajanPeter P StanichKimberly ChildersSandra BrownChristine M DroganGiulia Martina CavestroKelly GordonAparajita SinghDiane M SimeoneHannah ReichFay KastrinosDana ZakalikHeather HampelRachel PearlmanOra K GordonSonia S KupferMarta PuzzonoRaffaella Alessia ZuppardoRandall E BrandPublished in: Cancer (2024)
Most PV/LPV carriers who developed PDAC did not have a close family history of PDAC and would not have met most current professional societies' recommendations for consideration of PDAC surveillance before diagnosis. However, PV/LPV carriers were significantly more likely to have a family history of PDAC, particularly an affected FDR. These findings support family history as a risk modifier in PV/LPV carriers, and highlight the need to identify other risk factors.