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Impact of BRAF Mutation Class on Disease Characteristics and Clinical Outcomes in BRAF-mutant Lung Cancer.

Ibiayi Dagogo-JackPablo MartinezBeow Y YeapChiara AmbrogioLorin A FerrisChristine LydonTom NguyenNicholas A JessopA John IafrateBruce E JohnsonJochen K LennerzAlice T ShawMark M Awad
Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2018)
BRAF-mutant NSCLC is a heterogeneous disease that encompasses 3 distinct functional classes. Classes II and III have more aggressive clinical features leading to less favorable outcomes. The distinct biological characteristics of class II and III tumors suggest that class-specific therapies may be necessary to effectively target these molecular subsets.
Keyphrases
  • wild type
  • metastatic colorectal cancer
  • small cell lung cancer
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  • advanced non small cell lung cancer
  • type diabetes
  • single molecule
  • glycemic control