Aminoalcohol derivatives by nickel-catalyzed enantioselective coupling of imines and dienol ethers.
Jae Yeon KimThomas Q DaviesAlois FürstnerPublished in: Chemical communications (Cambridge, England) (2023)
The reductive coupling of dienol ethers with N -tosylimines catalyzed by Ni(0) in the presence of a VAPOL-derived phosphoramidite ligand follows an unprecedented regiochemical course; it furnishes syn -configured 1,2-aminoalcohol derivatives in good chemical yields with up to 94% ee.