The IRE1/JNK signaling pathway regulates inflammation cytokines and production of glomerular extracellular matrix in the acute kidney injury to chronic kidney disease transition.

Yan LiangLingyun QuZhenjie LiuLulu LiangYingzi WangSongxia QuanYulin WangLin Tang

Published in: Molecular biology reports (2022)

These findings suggested that the IRE1/JNK pathway regulates the inflammatory cytokines caused by AKI and continues to activate the STAT3 pathway and production of ECM in the glomeruli at late stages, suggesting the feasibility of targeted therapy for the AKI-CKD transition.

Keyphrases

acute kidney injury
extracellular matrix
signaling pathway
chronic kidney disease
induced apoptosis
endoplasmic reticulum stress
cardiac surgery
end stage renal disease
pi k akt
cell death
oxidative stress
epithelial mesenchymal transition
cell proliferation
cancer therapy
endothelial cells
high glucose