Protective paraspeckle hyper-assembly downstream of TDP-43 loss of function in amyotrophic lateral sclerosis.
Tatyana A ShelkovnikovaMichail S KukharskyHaiyan AnPasquale DimasiSvetlana AlexeevaOsman ShabirPaul R HeathVladimir L BuchmanPublished in: Molecular neurodegeneration (2018)
Our study establishes possible mechanisms behind paraspeckle hyper-assembly in ALS and suggests their utility as therapeutic targets in ALS and other diseases with abnormal metabolism of microRNA and dsRNA.
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