Feasibility of Targeting Traf2-and-Nck-Interacting Kinase in Synovial Sarcoma.

Tetsuya SekitaTesshi YamadaEisuke KobayashiAkihiko YoshidaToru HirozaneAkira KawaiYuko UnoHideki MoriyamaMasaaki SawaYuichi NagakawaAkihiko TsuchidaMorio MatsumotoMasaya NakamuraRobert NakayamaMari Masuda

Published in: Cancers (2020)

It has become evident that activation of Wnt signaling is causatively involved in the pathogenesis of synovial sarcoma, but no molecular therapeutics targeting the pathway have been approved. This study revealed for the first time the therapeutic potential of TNIK inhibition in synovial sarcoma.

Keyphrases

cancer therapy
protein kinase
small molecule
single cell
tyrosine kinase
single molecule