PDE5 inhibitors and male reproduction: Is there a place for PDE5 inhibitors in infertility clinics or andrology laboratories?
Fotios DimitriadisAris KaltsasAthanasios ZachariouCharalampos MamoulakisChara TsiampaliIoannis GiannakisMinas PaschopoulosAthanasios PapatsorisDimitrios LoutradisPanagiota TsounapiAtsushi TakenakaNikolaos SofikitisPublished in: International journal of urology : official journal of the Japanese Urological Association (2022)
The objective of this review study is to evaluate the therapeutic role of PDE5 inhibitors (PDE5is) in the amelioration of oligoasthenospermia in infertile males. PDE5is have a beneficial influence on the secretory function of the Leydig and Sertoli cells, the biochemical environment within the seminiferous tubule, the contractility of the testicular tunica albuginea, and the prostatic secretory function. In several studies, the overall effect of sildenafil and vardenafil increased quantitative and qualitative sperm motility. Furthermore, some studies indicate that PDE5is influence positively the sperm capacity to undergo capacitation under biochemical conditions that are known to induce the sperm capacitation process. Additional research efforts are necessary in order to recommend unequivocally the usage of sildenafil, vardenafil, or avanafil for the alleviation of male infertility.
Keyphrases
- pulmonary hypertension
- polycystic ovary syndrome
- pulmonary arterial hypertension
- induced apoptosis
- primary care
- systematic review
- type diabetes
- high resolution
- cell cycle arrest
- case control
- escherichia coli
- staphylococcus aureus
- adipose tissue
- cell proliferation
- biofilm formation
- cystic fibrosis
- cell death
- signaling pathway
- germ cell