Low Serum Bicarbonate and CKD Progression in Children.
Denver D BrownJennifer RoemDerek K NgKimberly J ReidyJuhi KumarMatthew K AbramowitzRobert H MakSusan L FurthGeorge J SchwartzBradley A WaradyFrederick J KaskelMichal L MelamedPublished in: Clinical journal of the American Society of Nephrology : CJASN (2020)
In children with glomerular disease, low bicarbonate was linked to a higher risk of CKD progression. Resolution of low bicarbonate was associated with a lower risk of CKD progression. Fewer than one half of all children with low bicarbonate reported treatment with alkali therapy. Long-term studies of alkali therapy's effect in patients with pediatric CKD are needed.