Metabolomic/lipidomic-based analysis of plasma to diagnose hepatocellular ballooning in patients with non-alcoholic fatty liver disease: A multicenter study.

Yuji OgawaTakashi KobayashiYasushi HondaTakaomi KessokuWataru TomenoKento ImajoTakashi NakaharaSatoshi OedaYuko NagaokiYuichiro AmanoTatsuya AndoMegumi HirayamaOsamu IsonoHidenori KamiguchiHiroshi NagabukuroShinji OgawaYoshinori SatomiYusuke SaigusaHirokazu TakahashiHideyuki HyogoMasato YonedaSatoru SaitoTakeharu YamanakaShinichi AishimaYuichiro EguchiMasayoshi KageKazuaki ChayamaAtsushi Nakajima

Published in: Hepatology research : the official journal of the Japan Society of Hepatology (2020)

Plasma levels of PC were positively correlated, and those of lysophosphatidylcholine and LPE were negatively correlated with hepatocellular ballooning in NAFLD patients. These non-invasive metabolic/lipidomic-based plasma tests might be useful to distinguish between cases of NAFLD with and without hepatocellular ballooning.

Keyphrases

end stage renal disease
newly diagnosed
ejection fraction
prognostic factors
peritoneal dialysis
patient reported