Metabolite profiling with HPLC-ICP-MS as a tool for in vivo characterization of imaging probes.
Eszter BorosOmar R PinkhasovPeter CaravanPublished in: EJNMMI radiopharmacy and chemistry (2018)
HPLC-ICP-MS is a robust, sensitive and radiation-free technique to characterize the pharmacokinetics and metabolism of imaging probes.
Keyphrases
- ms ms
- mass spectrometry
- high resolution
- fluorescence imaging
- simultaneous determination
- small molecule
- multiple sclerosis
- high performance liquid chromatography
- living cells
- single molecule
- tandem mass spectrometry
- solid phase extraction
- liquid chromatography
- radiation therapy
- photodynamic therapy
- radiation induced
- nucleic acid