Single-Cell Transcriptome Analysis Reveals Embryonic Endothelial Heterogeneity at Spatiotemporal Level and Multifunctions of MicroRNA-126 in Mice.

Fang-Hao GuoYa-Na GuanJun-Jun GuoLu-Jun ZhangJing-Jing QiuYong Ji Alex F Chen Qing Jing

Published in: Arteriosclerosis, thrombosis, and vascular biology (2022)

The heterogeneity of ECs is established as early as the embryonic stage. The deficiency of miR-126 disrupts the differentiation and diversification of embryonic ECs, suggesting that miR-126 plays an essential role in the maintenance of ECs heterogeneity.

Keyphrases

single cell
rna seq
cell proliferation
long non coding rna
long noncoding rna
high throughput
endothelial cells
high fat diet induced
adipose tissue