8-Hydroxyquinoline-5-sulfonamides are promising antifungal candidates for the topical treatment of dermatomycosis.

B PippiA R JoaquimW LopesG R M MachadoV Z BergamoL M GiulianiM A AbeggL CruzM H VainsteinA M FuentefriaSaulo Fernandes de Andrade

Published in: Journal of applied microbiology (2019)

There is an emerging need to fill the pipeline with new antifungal drugs due to the limitations presented by the currently used drugs. In this study, we have described a novel formulation with a 8-hydroxyquinoline-5-sulfonamide derivative which has presented a great potency in providing a finished product. Furthermore, the derivative has shown a selective mechanism of action confirming its potential to be developed into a new drug candidate.

Keyphrases

candida albicans
drug delivery
drug induced
emergency department
water soluble
high resolution
adverse drug
wound healing