Recent studies suggest an association between moderate to severe OSA and abnormal MBF/MFR. OSA promotes functional and structural abnormalities of the coronary microcirculation. OSA also promotes the uncoupling of MBF to cardiac work. In a handful of studies with small sample sizes, CPAP therapy improved MBF/MFR. Moderate to severe OSA is associated with abnormal MFR, suggesting an association with CMD. Evidence suggests that CPAP therapy improves MBF. Future studies must determine the clinical impact of improved MBF with CPAP.
Keyphrases
- obstructive sleep apnea
- positive airway pressure
- blood flow
- sleep apnea
- cardiovascular disease
- case control
- left ventricular
- early onset
- coronary artery disease
- high intensity
- coronary artery
- heart failure
- stem cells
- drug induced
- emergency department
- current status
- bone marrow
- cardiovascular events
- cell therapy
- ejection fraction