PAR-4/Ca2+-calpain pathway activation stimulates platelet-derived microparticles in hyperglycemic type 2 diabetes.

Alessandra GiannellaGiulio CeolottoClaudia Maria RaduArianna CattelanElisabetta IoriAndrea BenettiFabrizio FabrisPaolo SimioniAngelo AvogaroSaula Vigili de Kreutzenberg

Published in: Cardiovascular diabetology (2021)

These results identify PAR-4 as a mediator of platelet activation, microparticle release, and inflammation, in poorly controlled T2DM.

Keyphrases

type diabetes
glycemic control
oxidative stress
cardiovascular disease
metabolic syndrome
skeletal muscle
adipose tissue