He Jiankui et al. conducted an experiment that resulted in the birth of the first human babies with germline gene editing. Initial and predominant communications of their work occurred via social media and outside of the norms for reviewing, approving, and engaging around work in science. This case provides an opportunity to reflect on the evolving and increasing presence of social media in science, its strengths, weaknesses, and the potential to develop applications that improve how we review, approve, and engage around the work of science. Social media use in science presents significant challenges. The potential benefits of addressing these challenges and developing new social media tools include greater transparency, access, and engagement-and could nurture the public's trust. Stem Cells Translational Medicine 2019;8:1226&1229.