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Graphene Oxide Carboxymethylcellulose Nanocomposite for Dressing Materials.

Maria Luisa SaladinoMarta MarkowskaClara CarmonePatrizia CancemiRosa AlduinaAlessandro PresentatoRoberto ScaffaroDariusz BiałyMariusz HasiakDariusz HreniakMagdalena Wawrzyńska
Published in: Materials (Basel, Switzerland) (2020)
Sore, infected wounds are a major clinical issue, and there is thus an urgent need for novel biomaterials as multifunctional constituents for dressings. A set of biocomposites was prepared by solvent casting using different concentrations of carboxymethylcellulose (CMC) and exfoliated graphene oxide (Exf-GO) as a filler. Exf-GO was first obtained by the strong oxidation and exfoliation of graphite. The structural, morphological and mechanical properties of the composites (CMCx/Exf-GO) were evaluated, and the obtained composites were homogenous, transparent and brownish in color. The results confirmed that Exf-GO may be homogeneously dispersed in CMC. It was found that the composite has an inhibitory activity against the Gram-positive Staphylococcus aureus, but not against Gram-negative Pseudomonas aeruginosa. At the same time, it does not exhibit any cytotoxic effect on normal fibroblasts.
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