Antiviral 4-Hydroxypleurogrisein and Antimicrobial Pleurotin Derivatives from Cultures of the Nematophagous Basidiomycete Hohenbuehelia grisea.
Birthe SandargoBenjarong ThongbaiDimas F PradityaEike SteinmannMarc StadlerFrank SurupPublished in: Molecules (Basel, Switzerland) (2018)
4-Hydroxypleurogrisein, a congener of the anticancer-lead compound pleurotin, as well as six further derivatives were isolated from the basidiomycete Hohenbuehelia grisea, strain MFLUCC 12-0451. The structures were elucidated utilizing high resolution electron spray ionization mass spectrometry (HRESIMS) and 1D and 2D nuclear magnetic resonance (NMR) spectral data and evaluated for their biological activities; for leucopleurotin, we provide Xray data. While most congeners showed moderate antimicrobial and cytotoxic activity, 4-hydroxypleurogrisein emerged as an inhibitor of hepatitis C virus infectivity in mammalian liver cells.
Keyphrases
- high resolution
- magnetic resonance
- hepatitis c virus
- mass spectrometry
- staphylococcus aureus
- electronic health record
- induced apoptosis
- big data
- gas chromatography
- cell cycle arrest
- human immunodeficiency virus
- optical coherence tomography
- high performance liquid chromatography
- high speed
- structure activity relationship
- tandem mass spectrometry
- endoplasmic reticulum stress
- machine learning
- computed tomography
- oxidative stress
- cell proliferation
- solar cells
- artificial intelligence
- dual energy
- hiv infected