Survival of Patients With Cancer With DPYD Variant Alleles and Dose-Individualized Fluoropyrimidine Therapy-A Matched-Pair Analysis.
Jonathan E KnikmanTycho A WiltingMarta Lopez-YurdaLinda M HenricksCarin A T C LunenburgFemke M de ManDidier M MeulendijksPeter NieboerHelga J DroogendijkGeert-Jan M CreemersCaroline M P W MandigersAlexander L T ImholzRon H J MathijssenJohanneke E A PortieljeLiselot Valkenburg-van IerselAnnelie VulinkMarlene H W van der PoelArnold BaarsJesse Joachim SwenAndré B P van KuilenburgJan H M SchellensJos H BeijnenHenk-Jan GuchelaarAnnemieke CatsPublished in: Journal of clinical oncology : official journal of the American Society of Clinical Oncology (2023)
variant carriers. Close monitoring with early dose modifications based on toxicity is recommended, especially for c.1236G>A carriers receiving a reduced starting dose.
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