Determination of dose-response calibration curves for gamma radiation using gamma-H2AX immunofluorescence based biodosimetry.

Solomon Raj JosePeace Balasingh TimothyJ SuganthySelvamani BackianathanSoosai Manickam AmirthamSandya RaniRabi Singh

Published in: Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology (2024)

Based on this study we conclude that the individual dose-response calibration curves determined with gamma-H2AX immunofluorescence assay for both low and high dose ranges of gamma radiation can be used for biological dosimetry. Further, the gamma-H2AX immunofluorescence assay can be used as a rapid cost-effective biodosimetric tool for institutions with an existing confocal microscope facility.

Keyphrases

high dose
low dose
stem cell transplantation
optical coherence tomography
low cost
radiation therapy
high resolution
solid phase extraction