HIV-1 exposure and immune activation enhance sexual transmission of Hepatitis C virus by primary Langerhans cells.

Bernadien M NijmeijerRamin Sarrami-ForooshaniGaby S StebaRenée Rce SchreursSylvie M KoekkoekRichard MolenkampJanke SchinkelPeter ReissMatthijs L Siegenbeek van HeukelomMarc van der ValkCarla M S Ribeiro Teunis B H Geijtenbeek

Published in: Journal of the International AIDS Society (2020)

Thus, our data strongly indicate that HIV-1 or immune activation in MSM leads to capture of HCV by mucosal LCs, which might facilitate transmission to other cells or allow entry of HCV into the blood. This novel transmission mechanism by LCs also implicates that the activation state of LCs is an important cellular determinant for HCV susceptibility after sexual contact.

Keyphrases

hepatitis c virus
human immunodeficiency virus
induced apoptosis
cell cycle arrest
hiv testing
antiretroviral therapy
hiv positive
men who have sex with men
hiv infected
signaling pathway
machine learning
hiv aids
big data
electronic health record
deep learning
ulcerative colitis