A Small Molecular Multifunctional Tool for pH Detection, Fluorescence Imaging, and Photodynamic Therapy.
Qingbin ZengQianni GuoYaping YuanXiaoxiao ZhangWeiping JiangSa XiaoBin ZhangXin LouChaohui YeMaili LiuLouis-S BouchardXin ZhouPublished in: ACS applied bio materials (2020)
A smart multitool platform for theranostics would be useful for monitoring the administration of therapies in vivo. However, the integration of multiple functions into a single small-molecule platform remains a challenge. In this study, we developed a multifunctional probe based on a small-molecule platform. The properties of this probe were investigated via hyperpolarized 129 Xe NMR/MRI, fluorescence imaging in cells and in vivo, and photodynamic therapy (PDT) in tumor mouse models. This multifunctional probe shows good pH response across a broad range of pH values. It also exhibits excellent fluorescence in vivo for mapping its biodistribution. Additionally, it produces enough 1 O 2 radicals for in vivo PDT. The combination of these functionalities into a single small-molecule platform, rather than a bulky nanoconstruct, offers unique possibilities for molecular imaging and therapy.
Keyphrases
- photodynamic therapy
- fluorescence imaging
- small molecule
- high throughput
- drug delivery
- protein protein
- living cells
- cancer therapy
- quantum dots
- high resolution
- induced apoptosis
- magnetic resonance imaging
- single molecule
- mouse model
- magnetic resonance
- cell cycle arrest
- bone marrow
- metal organic framework
- computed tomography
- oxidative stress
- stem cells
- contrast enhanced
- solid state
- sensitive detection
- pet imaging
- mass spectrometry
- high density