Multi-layered ZIF-coated cells for the release of bioactive molecules in hostile environments.
Lei GanMiriam de J Velásquez-HernándezAnita Emmerstorfer-AugustinPeter WiedHeimo WolinskiSimone Dal ZilioMarcello B SolomonWeibin LiangChristian J DoonanPaolo FalcaroPublished in: Chemical communications (Cambridge, England) (2022)
Metal-organic framework (MOF) coatings on cells enhance viability in cytotoxic environments. Here, we show how protective multi-layered MOF bio-composite shells on a model cell system (yeast) enhance the proliferation of living cells exposed to hostile protease-rich environments via the dissolution of the shells and release of a protease inhibitor (antitrypsin).
Keyphrases
- metal organic framework
- induced apoptosis
- living cells
- cell cycle arrest
- fluorescent probe
- endoplasmic reticulum stress
- stem cells
- single cell
- oxidative stress
- single molecule
- cell death
- cell therapy
- highly efficient
- bone marrow
- gold nanoparticles
- reduced graphene oxide
- mesenchymal stem cells
- cell proliferation
- saccharomyces cerevisiae