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NH 4 OAc/DMSO-Promoted Benzylation of Pyrrolo[2,1- a ]isoquinolines.

Xiao-Hui ChenTsesong LhazomHai-Lei Cui
Published in: The Journal of organic chemistry (2023)
Benzylation of pyrrolo[2,1- a ]isoquinoline derivatives has been realized with various phenols by the use of ammonium acetate as a promoter (20 examples, up to 84% yield). DMSO served as the source of methylene and solvent. The employment of iron chloride as a catalyst can also afford the desired benzylated products in moderate to good yields (11 examples, up to a 74% yield).
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