Magnetic Resonance Parkinsonism Index Is Associated with REM Sleep Behavior Disorder in Parkinson's Disease.
Daniele UrsoSalvatore NigroBenedetta TafuriValentina GnoniMarco FilardiRoberto De BlasiK Ray ChaudhuriGiancarlo LogroscinoPublished in: Brain sciences (2022)
We investigated the association between the Magnetic Resonance Parkinsonism Index (MRPI) and REM sleep behavior disorder (RBD). We included 226 de novo PD patients (82 PD-RBD and 144 PD-noRBD) and 19 idiopathic RBD patients. Furthermore, 3T T1-weighted MR images were used for automated brainstem calculations. MRPI values were higher in the PD-RBD ( p = 0.004) compared to PD-noRBD patients. Moreover, MRPI proved to be a significant predictor of REM Behavior Disorder Screening Questionnaire scores in PD (β = 0.195, p = 0.007) and iRBD patients (β = 0.582, p = 0.003). MRPI can be used as an imaging marker of RBD in patients with de novo PD and iRBD.
Keyphrases
- magnetic resonance
- end stage renal disease
- ejection fraction
- newly diagnosed
- chronic kidney disease
- physical activity
- magnetic resonance imaging
- deep learning
- high resolution
- computed tomography
- contrast enhanced
- sleep quality
- photodynamic therapy
- molecular dynamics simulations
- single molecule
- atomic force microscopy
- deep brain stimulation