Effect of Radiotherapy on Activating the Pyroptotic Cell Death Pathway in Breast Cancer Patients: The Role of Serum GSDMD-CT, NLRP3 and IL-18.
Taha Ismail Mahmoud HewalaYasmine Nagy ElwanyHossam EllmasryAyman ElrhawyPublished in: Asian Pacific journal of cancer prevention : APJCP (2024)
Radiotherapy induced pyroptosis in breast cancer patients as a new cell death mechanism. GSDMD-CT, NLRP3 and IL-18 are biomarkers of pyroptosis that significantly increased post irradiation highlighting enhanced ROS and pyroptosis induction.
Keyphrases
- cell death
- nlrp inflammasome
- early stage
- image quality
- dual energy
- radiation induced
- computed tomography
- locally advanced
- contrast enhanced
- cell cycle arrest
- radiation therapy
- high glucose
- positron emission tomography
- signaling pathway
- diabetic rats
- magnetic resonance imaging
- squamous cell carcinoma
- rectal cancer
- dna damage
- endothelial cells
- cell proliferation
- magnetic resonance
- reactive oxygen species