Immune endotyping and gene expression profile of patients with chronic rhinosinusitis with nasal polyps in the aspirin-exacerbated respiratory disease (AERD) and the non-AERD subgroups.

Javad NazariFaezeh ShahbaNegin JafariaghdamSaleh MohebbiSaba ArshiMohammad Hassan BemanianMorteza FallahpourSima ShokriFatemeh AtashrazmSaeed AminiMaryam RoomianiMahnaz JameePegah BabaheidarianMajid KhoshmirsafaMohammad Nabavi

Published in: Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology (2024)

Higher gene expression levels of GATA3, IL4, IL5, and IL17 were observed in the AERD group compared with the non-AERD group. These findings point to distinct patterns of inflammation in patients with AERD, with a predominance of Th2 inflammation.

Keyphrases

chronic rhinosinusitis
gene expression
oxidative stress
low dose
dna methylation
genome wide
type diabetes
antiplatelet therapy
acute coronary syndrome
atrial fibrillation