Ultra High-plex Spatial Proteogenomic Investigation of Giant Cell Glioblastoma Multiforme Immune Infiltrates Reveals Distinct Protein and RNA Expression Profiles.

Shilah A Bonnett Alyssa B Rosenbloom Giang T Ong Mark Conner Aric B E Rininger Daniel J Newhouse Felicia New Chi Q Phan Saskia Ilcisin Hiromi Sato John S Lyssand Gary Geiss Joseph M Beechem

Published in: Cancer research communications (2023)

We describe ultra high-plex spatial proteogenomics; profiling whole transcriptome and high-plex proteomics on a single FFPE tissue section with spatial resolution. Investigation of gcGBM versus GBM revealed distinct protein and RNA expression profiles.

Keyphrases

single cell
giant cell
high resolution
gene expression
mass spectrometry
amino acid
protein protein
rna seq
genome wide
small molecule
binding protein
dna methylation
label free