The feeding behaviour of Amyotrophic Lateral Sclerosis mouse models is modulated by the Ca2+ -activated KCa 3.1 channels.
Germana CocozzaStefano GarofaloMarta MorottiGiuseppina CheceAlfonso GrimaldiMario LecceFerdinando ScavizziRossella MenghiniViviana CasagrandeMassimo FedericiMarcello RaspaHeike WulffCristina LimatolaPublished in: British journal of pharmacology (2021)
Using ALS mouse models, we describe defects in the hypothalamic melanocortin system that affect appetite control. These results reveal a new regulatory role for KCa 3.1 to counteract weight loss in ALS.