Copy-number analysis of Y-linked loci in young men with non-obstructive azoospermia: Implications for the rarity of early onset mosaic loss of chromosome Y.

Erina SuzukiYoshitomo KoboriMomori KatsumiKikumi UshijimaToru UchiyamaHiroshi OkadaMami Miyado Maki Fukami

Published in: Reproductive medicine and biology (2020)

This study highlights the rarity of leukocyte mLOY in reproductive-aged men with spermatogenic failure. In addition, our data imply that standard karyotyping is sufficient to screen early onset mLOY.

Keyphrases

early onset
copy number
mitochondrial dna
genome wide
late onset
middle aged
dna methylation
electronic health record
high throughput
big data
deep learning