Beneficial actions of a long-acting apelin analogue in diabetes are related to positive effects on islet cell turnover and transdifferentiation.

Neil TandayNigel IrwinR Charlotte MoffettPeter R FlattFinbarr P M O'Harte

Published in: Diabetes, obesity & metabolism (2020)

Taken together these data demonstrate, for the first time, that pancreatic islet benefits of sustained APJ receptor activation in diabetes are linked to favourable islet cell transition events, leading to maintenance of β-cell mass.

Keyphrases

single cell
type diabetes
cell therapy
cardiovascular disease
stem cells
adipose tissue
electronic health record
bone marrow
mesenchymal stem cells
deep learning
artificial intelligence
weight loss
binding protein
drug induced