Selective DRD2 antagonist and ClpP agonist ONC201 in a recurrent non-midline H3 K27M-mutant glioma cohort.

Yazmin OdiaMatthew D HallTimothy Francis CloughesyPatrick Y WenIsabel C Arrillaga-RomanyDoured DaghistaniMinesh P MehtaRohinton S TaraporeSamuel C RamageJoshua E Allen

Published in: Neuro-oncology (2024)

H3 K27M-mutant diffuse gliomas occasionally occur in non-midline cerebrum. ONC201 exhibits activity in H3 K27M-mutant gliomas irrespective of CNS location.

Keyphrases

high grade
wild type
low grade
blood brain barrier