Acetazolamide and topiramate lower intracranial pressure through differential mechanisms- the effect of acute and chronic administration.
Connar Stanley James WestgateChristina Kamp-JensenIda Marchen Egerod IsraelsenTrine Toft-BertelsenJonathan Henry WardmanChristian Ahm JensenBjarne StyrishaveNanna MacAulayRigmor Hoejland JensenSajedeh EftekhariPublished in: British journal of pharmacology (2023)
Acetazolamide and topiramate are effective at lowering ICP at therapeutic levels. We provide the first evidence that topiramate lowers CSF secretion and that acetazolamide and topiramate may lower ICP via distinct molecular mechanisms. Thus, the combination of acetazolamide and topiramate may have utility for treating raised ICP.