Smoking Status, Nicotine Medication, Vaccination, and COVID-19 Hospital Outcomes: Findings from the COVID EHR Cohort at the University of Wisconsin (CEC-UW) Study.
Thomas M PiaseckiStevens S SmithTimothy B BakerWendy S SlutskeRobert T AdsitDaniel M BoltKaren L ConnerSteven L BernsteinOliver D EngDavid LazukAlec GonzalezDouglas E JorenbyHeather D'AngeloJulie A KirschBrian S WilliamsMargaret B NolanTodd Hayes-BirchlerSean KentHanna KimStan LubanskiMenggang YuYoumi SukYuxin CaiNitu KashyapJomol P MathewGabriel McMahanBetsy RollandHilary A TindleGraham W WarrenLawrence C AnAndrew D BoydDarlene H BrunzellVictor CarrilloLi-Shiun ChenJames M DavisVikrant G DeshmukhDeepika DilipEdward F EllerbeckAdam O GoldsteinEduardo IturrateThulasee JoseNiharika KhannaAndrea KingElizabeth KlassRobin J MermelsteinElisa K TongJanice Y TsohKaren M WilsonWendy E TheobaldMichael C FiorePublished in: Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco (2022)
Prior findings regarding associations between smoking and severe COVID-19 disease outcomes have been inconsistent. This large cohort study suggests potential beneficial effects of nicotine replacement therapy on COVID-19 outcomes in current smokers and outsized benefits of SARS-CoV-2 vaccination in current and former smokers. Such findings may influence clinical practice and prevention efforts and motivate additional research that explores mechanisms for these effects.