Indole-3-Propionic Acid, a Gut-Derived Tryptophan Metabolite, Associates with Hepatic Fibrosis.

Ratika SehgalMariana Ilha Maija Vaittinen Dorota KaminskaVille MännistöVesa KärjäMarjo TuomainenKati HanhinevaStefano RomeoPäivi PajukantaJussi PihlajamäkiVanessa D de Mello

Published in: Nutrients (2021)

The association of circulating IPA with liver fibrosis and the ability of IPA to reduce activation of LX-2 cells suggests that IPA may have a therapeutic potential. Further molecular studies are needed to investigate the mechanisms how IPA can ameliorate hepatic fibrosis.

Keyphrases

liver fibrosis
induced apoptosis
cell cycle arrest
cell death
cell proliferation