Exercise activates the hypothalamic S1PR1-STAT3 axis through the central action of interleukin 6 in mice.
Vagner Ramon Rodrigues SilvaThayana O MichelettiCarlos K KatashimaLuciene LenhareJoseane MorariAlexandre Moura-AssisJosé C de Lima-JúniorJuliana A CamargoGabriela R PassosRodrigo S GasparLicio A VellosoMario J SaadAdelino Sanchez Ramos da SilvaLeandro P MouraDennys E CintraJosé R PauliEduardo R RopellePublished in: Journal of cellular physiology (2018)
Hypothalamic sphingosine-1-phosphate receptor 1 (S1PR1), the G protein-coupled receptor 1 of sphingosine-1-phosphate, has been described as a modulator in the control of energy homeostasis in rodents. However, this mechanism is still unclear. Here, we evaluate the role of interleukin 6 (IL-6) associated with acute physical exercise in the control of the hypothalamic S1PR1-signal transducer and activator of transcription 3 (STAT3) axis. Acute exercise session and an intracerebroventricular IL-6 injection increased S1PR1 protein content and STAT3 phosphorylation in the hypothalamus of lean and obese mice accompanied by a reduction in food consumption. Transcriptome analysis indicated a strong positive correlation between Il-6 and S1pr1 messenger RNA in several tissues of genetically diverse BXD mice strains and humans, including in the hypothalamus. Interestingly, exercise failed to stimulate the S1PR1-STAT3 axis in IL-6 knockout mice and the disruption of hypothalamic-specific IL-6 action blocked the anorexigenic effects of exercise. Taken together, our results indicate that physical exercise modulates the S1PR1 protein content in the hypothalamus, through the central action of IL-6.
Keyphrases
- high intensity
- cell proliferation
- physical activity
- liver failure
- gene expression
- transcription factor
- drug induced
- intensive care unit
- hepatitis b virus
- risk assessment
- type diabetes
- binding protein
- skeletal muscle
- aortic dissection
- extracorporeal membrane oxygenation
- acute respiratory distress syndrome
- human health