A semi-mechanistic pharmacokinetic/pharmacodynamic model for alanine aminotransferase-based hepatotoxicity of methotrexate in paediatric patients with acute lymphoid leukemia.

Qiufen YinZeneng ChengMinghua YangShengfeng WangFeifan Xie

Published in: British journal of clinical pharmacology (2023)

A semi-mechanistic model was developed to describe ALT-based hepatotoxicity of MTX, and it has the potential to serve as a valuable tool for characterizing drug-induced hepatotoxicity.

Keyphrases

drug induced
liver injury
intensive care unit
emergency department
adverse drug
acute myeloid leukemia
high dose
bone marrow
human health