CD4+ T helper 17 cell response of aged mice promotes prostate cancer cell migration and invasion.
Sen LiuFengli LiuBing ZhangPeng YanBrian G RowanAsim B Abdel-MageedChad SteeleS Michal JazwinskiKrzysztof MorozElizabeth B NortonAlun WangLeann MyersA Oliver SartorQiuyang ZhangPublished in: The Prostate (2020)
These results indicate that age-related CD4+ T cells, especially Th17 cells-secreted factors have the potential to contribute to prostate carcinogenesis. Our work could prompt further research using autochthonous PCa mouse models at different ages to elucidate the functional role of Th17 response in prostate carcinogenesis during aging.
Keyphrases
- prostate cancer
- single cell
- radical prostatectomy
- cell therapy
- induced apoptosis
- mouse model
- benign prostatic hyperplasia
- regulatory t cells
- cell cycle arrest
- dendritic cells
- immune response
- type diabetes
- adipose tissue
- metabolic syndrome
- bone marrow
- high fat diet induced
- insulin resistance
- endoplasmic reticulum stress