Cervical cancer screening cotesting with cytology and MRNA HPV E6/E7 yields high rates of CIN2+ lesions in young women.

Rosario GranadosHilda Tellez-SafinaIsabel SolisFrancisco MateosJose Maria Rodriguez-BarberoJose Antonio AramburuMiguel Angel HuertasPaloma BajoEncarnacion CamarmoTeresa CorralesPedro MedinaBeatriz CalvoEsther MartinLaura AntaManuel ZamoraTeresa Alcaide

Published in: Diagnostic cytopathology (2017)

Aptima HPV shows a significantly higher sensitivity for cervical CIN2+ lesions than cytology alone. Unexpectedly, AHPV-positive women under 35 had the highest incidence of CIN2+ lesions, particularly when they are HPV16/18/45-positive. Reconsidering HPV primary screening before the recommended age of 35 is warranted.

Keyphrases

cervical cancer screening
high grade
fine needle aspiration
risk factors
ultrasound guided
binding protein
polycystic ovary syndrome
pregnant women