Advanced statistics identification of participant and treatment predictors associated with severe adverse effects induced by fluoropyrimidine-based chemotherapy.

Samantha K KorverJoanne M BowenRachel J GibsonImogen A BallKate R SecombeTaylor J WainRichard M LoganJonathan TukeKelly R MeadAlison M RichardsChristos S KarapetisDorothy M KeefeJanet K Coller

Published in: Cancer chemotherapy and pharmacology (2023)

This study is the first to link both genetic and non-genetic predictors with adverse effects following fluoropyrimidine-based chemotherapy. Collectively, we report a wealth of information that warrants further investigation to elucidate the clinical significance, especially associations with genetic predictors and adverse effects.

Keyphrases

genome wide
copy number
gene expression
healthcare
dna methylation
drug induced