Novel Role of Endothelial CD45 in Regulating Endothelial-to-Mesenchymal Transition in Atherosclerosis.

Qianman PengKulandaisamy ArulsamyYao Wei LuHao WuBo ZhuBandana SinghKui CuiJill Wylie-SearsKathryn S LiScott WongDouglas B CowanMasanori AikawaDa-Zhi WangJoyce BischoffKaifu ChenHong Chen

Published in: bioRxiv : the preprint server for biology (2024)

These findings demonstrate that the loss of endothelial CD45 protects against EndoMT-driven atherosclerosis, promoting KLF2 expression while inhibiting TGFβ signaling and EndoMT markers. Thus, targeting endothelial CD45 may be a novel therapeutic strategy for EndoMT and atherosclerosis.

Keyphrases

endothelial cells
cardiovascular disease
stem cells
nk cells
bone marrow
type diabetes
cancer therapy
binding protein
drug delivery