Protect, Repair, and Regenerate: Towards Restoring Vision in Glaucoma.
Lauren K WarehamMichael L RisnerDavid John CalkinsPublished in: Current ophthalmology reports (2020)
Identification and manipulation of intrinsic and extrinsic cellular mechanisms that promote axon regeneration in both resident and transplanted RGCs will drive future advances in vision restoration. Understanding the roles of multiple cell types in the retina that act in concert to promote RGC survival will aid efforts to promote neuronal health and restoration. Effective RGC transplantation, fine tuning axon guidance and growth, and synaptogenesis of transplanted and resident RGCs are still areas that require more research.