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Pharmacological Characterization of a Novel Neuroactive Steroid Prodrug, NTS-104, and Its Neuroprotective Activity in Experimental Stroke Models.

Li ZhangRobin Schwartz-ByrneSteven GertzMatthew McGuireColleen WoodhouseBrianna PowellMin WeiChao LiClare B BillingTodd A VerdoornLeslie LamTom J ParryBenjamin BullerZheng Gang ZhangDavid PoulsenMichael Chopp
Published in: Stroke (2022)
NTS-104 is a novel prodrug that converts to a novel neuroactive steroid, NTS-105, which improves functional outcomes in experimental ischemic stroke models.
Keyphrases
  • atrial fibrillation
  • cancer therapy
  • drug release
  • cerebral ischemia
  • blood brain barrier