Pharmacological Characterization of a Novel Neuroactive Steroid Prodrug, NTS-104, and Its Neuroprotective Activity in Experimental Stroke Models.
Li ZhangRobin Schwartz-ByrneSteven GertzMatthew McGuireColleen WoodhouseBrianna PowellMin WeiChao LiClare B BillingTodd A VerdoornLeslie LamTom J ParryBenjamin BullerZheng Gang ZhangDavid PoulsenMichael ChoppPublished in: Stroke (2022)
NTS-104 is a novel prodrug that converts to a novel neuroactive steroid, NTS-105, which improves functional outcomes in experimental ischemic stroke models.